GLP-1 RAs can reliably treat a known risk factor for developing lymphedemaelevated BMI
Avoid lumbar hyperextension exercises, heavy axial loading (squats, deadlifts) during the acute phase, and any movement that reproduces radiating symptoms
Most users report only mild nausea at top dose
If BMI requirements are met, it can be prescribed off-label for weight loss
Safe evidence-based approaches include gradual caloric deficit (not rapid restriction), regular moderate exercise, meal planning, and behavioral support
Therefore, we performed a re-plating assay and a limiting dilution sphere formation assay for the cell line Calu-6, allowing us to investigate long-term intrinsic replating capacity and self-renewal of these end-stage clonogenic surviving cells (Fig