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Semaglutide slows stomach emptying as part of its weight loss mechanism, which can increase stomach acid production and create conditions favorable for reflux

Its phase 2 and phase 3 data set spans thousands of participants across the SURPASS and SURMOUNT trial programmes, giving researchers an extensive published literature base against which to calibrate experimental design and expected outcomes

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GLP-1 medications slow emptying further, which can cause severe nausea

Strength training two to four times weekly provides the anabolic stimulus needed to preserve lean mass during weight loss, and it improves insulin sensitivity independently of the medication

The expanding role of semaglutide: beyond glycemic control