One challenge to elucidating a mechanistic role for GLP-1Rs stems from their complex expression across multiple brain regions (1012), including the lateral septal nucleus (LSc), substantia nigra, ventral tegmental area (VTA), amygdala, nucleus accumbens (ACB), hippocampus, several regions of the hypothalamus (paraventricular nucleus of the hypothalamus [PVH], arcuate nucleus [ARH]), and hindbrain
Generics require FDA approval by demonstrating bio-equivalence to the brand-name drug
doi:10.1080/17512433.2022.2054413
These data make dual agonism the bridge between classical GLP-1 mono-agonism and triple agonism, which adds a third receptor
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Adipose tissue releases adipokines, specific proteins that directly target and destroy joint cartilage at a cellular level, even in non-weight-bearing joints like the hands
