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Glucagon-like peptide-1 (GLP-1) is a naturally occurring hormone your intestines release after eating, signaling fullness to your brain and slowing stomach emptying

Injection timing also matters

Because retatrutide is administered as a once-weekly subcutaneous injection, its long pharmacokinetic half-life estimated at approximately six days in the Phase 2 trial data means that plasma concentrations remain relatively stable throughout the week

In hereditary or acquired metabolic defects, an initial intravenous bolus of 50 mg/kg may be administered over two to three minutes, followed by maintenance doses of 50 mg/kg every six hours or continuous infusion to achieve a total daily exposure of up to 300 mg/kg in critical illness

Studies also show that vitamin C can help regenerate glutathione by converting oxidized glutathione back to its active form 6

But we know that people with diabetes taking tirzepatide (and other weight loss medications) lose less weight on average than those without diabetes