However, the metabolic improvements and weight loss associated with GLP-1 therapy may indirectly affect hormonal factors that influence acne severity
Inhibition of tyrosinase and melanin synthesis Glutathione interferes with the activity of tyrosinase, the ratelimiting enzyme that converts tyrosine into dopa and dopaquinone, the first steps in melanin production
Bigler J, Whitton J, Lampe JW, Fosdick L, Bostick RM, Potter JD
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This results in cleaved glutamate, cysteine and glycine while facilitating the transfer of -glutamyl moiety of GSH to either water (hydrolysis) or substrates such as peptides (transpeptidation)
Although the exact reason for the local proliferation of naevus cells is unknown, it is clear that the number of melanocytic naevi a person has depends on genetic factors, on sun exposure, and on immune status