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Semaglutide carries a Boxed Warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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The influence of GLP-1 on glucose stimulated insulin secretion:effects on -cell sensivity in type 2 and nondiabetic subjects