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Maintaining regular meals, adequate hydration, and standing up slowly can help reduce symptoms

Patients with favorable genetic profiles for GLP-1 response often experience faster appetite suppression and steadier weight loss

These titration schedules balance achieving therapeutic levels with minimizing nausea, vomiting and other gastrointestinal effects that commonly occur when GLP 1 medications are started or increased too quickly

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Extreme caloric restriction while on semaglutide can lead to muscle loss, nutritional deficiencies, and metabolic adaptation that makes long-term weight maintenance harder

References: Khavinson, V