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Semaglutide is clinically indicated for adults with a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related comorbidity such as Type 2 diabetes, hypertension, high cholesterol, or cardiovascular disease
While its marketed as a diabetes-controlling medication, its also well-known for its frequent off-label use as a weight loss aid
PMID: 10 CoteGJGrubbsEGHofmannM-C
Conditional knockout work has narrowed this but not closed it
Several clinical trials have demonstrated its effectiveness in promoting significant weight loss in obese patients
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