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First, the effect is enzymatic and cumulative you are shifting a metabolic set-point over days and weeks, not triggering an acute hormonal event, which is why steady daily exposure matters more than any single large dose

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Minoxidil initially produces vellus-like hairs that are soft and downy, gradually transitioning to terminal hairs matching the surrounding scalp

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[1] Whilst vitamin B12 deficiency can cause serious health consequences including megaloblastic anaemia and neurological damage, supplementation is generally considered safe