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Investigations have revealed that the orphan nuclear receptor NR4A1 is pivotal in mediating metformins protective effects against endothelial dysfunction induced by high glucose levels

Canli , Alanku YB, Grootjans S, Vegi N, Hltner L, Hoppe PS, et al

Medicine 73 , 17 (1994)

Thus, SARS-CoV-2 proteins could sense the host cellular metabolic status and trigger human metabolic reprogramming/dysregulation (HMRD) in the infected human host

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