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However, most methods of obtaining darker coloured skin offer no health benefits and can lead to unpleasant side effects or life-threatening conditions in some cases.

Ask a male who is on TRT (Testosterone replacement therapy) due to low Testosterone production the same question, and you might get a completely different answer

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Symptoms can be mild to severe and fluctuate dramatically

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MC1R activation on melanocytes upregulates tyrosinase and downstream melanin-biosynthesis enzymes, which is why Melanotan II is a standard tool compound in melanogenesis and pigmentation research