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Inflammation in the CNS increases the risk of AD initiation and exacerbates the amyloid and tau pathology and the cognitive decline [12]

Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, Rosenberg IH

In addition, S proteins are highly affiliated to the angiotensin-converting enzyme (ACE2) receptors, which are highly expressed in human epithelial cells [56]

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4.2 Ferroptosis induction: an emerging cell death mechanism Beyond its established roles in apoptosis and cell cycle arrest, SFN demonstrates significant capacity to induce ferroptosisan iron-dependent form of regulated cell death characterized by lethal lipid peroxide accumulation

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