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Los mecanismos fisiolgicos incluyen : adaptacin metablica con reduccin del gasto energtico en reposo, cambios en las hormonas intestinales (GLP-1, PYY, grelina), y dilatacin gradual del reservorio gstrico que permite mayor ingesta calrica
By performing a GWAS in the tirzepatide-treated population alone (Supplementary Table 12), we identified an association between the vomiting side effect and GIPR (rs71338792, P = 4.2 10 9 , odds ratio = 1.84
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We identified key regions in the p53 transactivation domain (TAD) involved in FOXO4 binding and designed an optimized peptide inhibitor (CPP-CAND) with improved cell permeability
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El-Sheikh AA, Rifaai RA
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