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The rationale is mechanistic, not empirical

Studies have shown

Meininger CJ, Marinos RS, Hatakeyama K, Martinez-Zaguilan R, Rojas JD, Kelly KA, et al

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This stable gastric penta-decapeptide was used also to provide new insights in treatment of colitis and ischemia and reperfusion in rats, where it was able to quickly restore blood supply to the ischemically injured areas and rapidly activated the growth rate of collateral blood vessels involved the NO system

Prolonged stimulation of GH and IGF-1 secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults