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Keep a symptom diary noting bowel frequency, consistency (using the NHS Bristol Stool Chart as reference), associated symptoms, and dietary intake

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Read more: Semaglutide: beware of buying the weight-loss drug online Participants were also told to reduce their daily calorie intake by around 500 calories per day and increase the amount of physical activity they did each week (aiming for around 150 minutes)

EMPs for each drug individually were $0.86 for topiramate and $0.53 for phentermine (total of $1.39 per course) based on API export data

These drugs combine weak opioid effects with norepinephrine reuptake inhibition