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In conclusion, loss of the BBB integrity, caused by the damage of any of its specific cellular component, leads to its functional failure and in turn to cerebrovascular dysfunction, neuroinflammation and neurodegeneration, contributing also to AD development (Desai et al., 2007

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Slowed gastric emptying continues without major fluctuations, helping with satiety and portion control

Human presenilin-1, but not familial Alzheimers disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

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