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It also reduced a secondary kidney composite outcome (sustained 50% eGFR decline, ESKD, or renal death) by 44%

Patients with DPN frequently experience symmetric sensory disturbances, typically presenting as pain, tingling, and prickling sensations and negative symptoms such as numbness [77]

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This is because it is involved in the transport of fatty acids into the mitochondria making it an essential component of L-Carnitine supplementation