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Some patients discontinue treatment due to gastrointestinal discomfort before reaching their weight loss goals

Simply apply gentle pressure if bleeding occurs

The preclinical studies were powered based on power calculations on the endpoints with highest variability (alanine aminotransferase and Col1 area %) in previous studies

The sensitivity analysis (individuals with BMI 30 kg/m 2 ) generally reinforced findings from the BMI 27 kg/m 2 population, with both GLP-1 RAs demonstrating consistent associations with better ocular outcomes compared to traditional anti-obesity medications (Fig

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P = .005)