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Moreover, depression is characterized by high prevalence of coexistence with many metabolic diseases, such as type 2 diabetes mellitus (T2DM) and obesity, and brain insulin resistance observed in both of these diseases is currently considered an important factor which may lead to the manifestation of depressive symptoms [10, 11]

However, other research suggests L-carnitine provides no benefits

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The practical options include extending the titration schedule (e.g., spending 8 weeks instead of 4 at each semaglutide dose level), reducing to the last tolerated dose, or temporarily holding the drug for 1-2 weeks while aggressive electrolyte repletion occurs