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These data suggest that GH may alter the clearance of compounds known to be metabolized by CYP450 liver enzymes (e.g., corticosteroids, sex steroids, anticonvulsants, cyclosporine)

Animal research provides valuable mechanistic understanding but doesn't guarantee identical effects or safety in humans

Further studies are thus required to better understand the interface of these two clinical challenges

A history of other substance use, higher socioeconomic status, or exposure to family violence or substance abuse has also been reported more often in this population (37, 38)

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