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Chromatography was performed on a Kinetex 2.6 m HILIC 100 , 100 2.1 mm internal diameter column (Phenomenex), with a constant flow rate of 250 l/min and a solvent gradient from 20% Mobile Phase B (50:45:5, ACN:H 2 O:100 mM AmFm in H 2 O) to 22% B at 5 min, 40% B at 10 min, 60% B at 13 min, 80% B at 15 min, and 99% B at 20 min

PROBAST: a tool to assess risk of bias and applicability of prediction model studies: explanation and elaboration

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This localized approach allows the peptide to target the injured tissues directly, enhancing the healing process

To provide a direct test of whether etomoxir could alleviate ER stress caused by the accumulation of misfolded protein, we examined its ability to reverse ER stress associated with overexpression of the null Hong Kong (NHK) protein