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Further, semaglutide stimulated the anti-inflammatory markers of M2 microglia subset and the cAMP/PKA/p38 pathway, which in turn stimulated the expression of cell-specific anti-inflammatory factors, interleukin-10 and IL-4 (Tamayo-Trujillo et al
Weight loss at 80 weeks (efficacy estimand): Cardiometabolic risk factors at 80 weeks (12 mg): triglycerides -37.0% , hsCRP -51.2% , non-HDL cholesterol -16.5% , systolic blood pressure -9.3 mmHg , waist circumference -7.5 in (19.0 cm)
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