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Both physiological and pathological environments were mimicked, with variations in O 2 levels (in both normoxic and hypoxic conditions) for 20 h to simulate cellular responses to mechanical and environmental stimuli [220]

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Phenolic compounds, such as isorhamnetin and piscidic acid derived from Opuntia ficus-indica , markedly decreased cholesterol permeability across a Caco-2 cell monolayer by 38%