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Transcriptomic analyses indicate that only a limited proportion of stress-responsive genes exhibit additive regulation during stress combinations, whereas most display synergistic, antagonistic, or unique expression patterns (Rizhsky et al., 2004
Sun C, Sha S, Shan Y, Gao X, Li L, Xing C, Guo Z, Du H
Journal of internal medicine 278, 16673 (2015)
Topical formulations (0.1-1% cream) present negligible systemic copper absorption and are not the focus of hepatic impairment concerns [1]
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