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However, only Wegovy has approval for use in managing weight

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It may only be used lawfully within an authorised clinical trial or under a specific MHRA-regulated framework for unlicensed medicines

Under low oxygen conditions, HIF-1 stabilizes and activates, regulating the expression of thousands of genes including glycolytic enzymes, Vascular Endothelial Growth Factor (VEGF), and Erythropoietin (EPO) (Figure 2

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