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Instead, a totality-of-evidence approach is required, supported by highly sensitive and orthogonal analytical methods to ensure equivalence in quality, safety, and efficacy

DFO reduced chronic inflammation and symptoms of autoimmune diseases in animal studies (Figure 11A), resulting in amplified transcription of genes promoting erythropoiesis, glycolysis, and angiogenesis (Woo et al., 2006)

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Therefore, it is probable that a broad spectrum of colon alterations may be induced by anthraquinone laxatives, which may lead to an accumulation of pigment or an altered neural function or both

Risks: Risk of redness, irritation, peeling, and temporary discomfort

10.1093/jexbot/53.372.1305 122 ShimaokaT.YokotaA.MiyakeC