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The Phase 3 data at 68 weeks showed continued weight loss at a rate that suggested the plateau, if it exists, lies beyond 68 weeks

Ther Adv Endocrinol Metab 10:2042018819863226

Researchers also suggest a potential connection to copper uptake in cells, which could support copper-dependent enzymatic processes

using a rodent model showed that one week of HFD leads to insulin resistance during a hyperinsulinemic-euglycemic clamp, impaired muscle MBF (assessed via CEU), abolished insulin-stimulated Akt and eNOS phosphorylation and increased inflammation in the aorta but not in muscle [67]

However, STING overexpression attenuated these protective effects

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