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For assessing the change in relative IBA1 or GFAP abundance at different doses of LPS, a linear model was constructed for each protein (IBA1 or GFAP) and each brain region (hippocampus or entire brain) using the protein percentage as dependent variable and treatment (veh-PBS, veh-LPS-0.05, veh-LPS-0.1, veh-LPS-0.5, and veh-LPS-1.0) and time (2 days and 11 days after the last LPS injection) as independent variables with interactions effects

Choose Reta + MOTS-c when mitochondrial support during the deficit matters more than full GH-axis recomp

In contrast, the subjects of clinical trials are complex patient populations, particularly elderly individuals with comorbid sarcopenia, obesity, or multiple metabolic diseases, whose muscle metabolic foundation is more fragile [63]

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Visual inspection before each injection is a critical safety practice for all GLP-1 medication users