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Upon binding to IGF-1R, the peptide initiates multiple intracellular signaling cascades, including the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway, which regulates protein synthesis and cell growth, and the mitogen-activated protein kinase (MAPK) pathway, which controls cell proliferation and survival

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Many studies indicate the critical importance of the exact chemical speciation of essential trace elements (Templeton et al., 2000) in determining their biological activity (Michalke et al., 2018)