Docking results of glutathione at the hTYR binding pocket reveal two potential binding modes
These compounds bind to the GLP-1 receptor, a G protein-coupled receptor (GPCR) expressed mainly in pancreatic -cells, hypothalamic neurons, and peripheral tissues
Vehicle control and no-cell control wells also were included
BioMed J (2021) 44(4):43946
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For instance, ECL1 that primarily interacts with six peptide positions (11 P , 14 P , 15 P , 18 P , 22 P and 25 P ) maintains a robust short -helix adjacent to TM2 for GLP-1R and TM3 for GCGR, respectively, regardless of the bound peptides (Fig