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There are virtually no data to inform best practice in the care of people with diabetes and advanced CKD, particularly in dialysis-dependent kidney disease

If a patient does not lose at least 5% of their body weight after several months, doctors may consider switching to another therapy or adjusting the plan

Archives of Disease in Childhood

Omega-3 fatty acids: 1,000 to 2,000 mg combined EPA and DHA daily Calcium citrate: 500 to 700 mg daily in split doses, especially for women and those over 50 Creatine monohydrate: 3 to 5 grams daily, especially for those doing resistance training Electrolyte supplement: Daily during dose escalation, as needed during maintenance Probiotics: 10 to 30 billion CFUs multi-strain, especially during first three months Tier 3: targeted supplementation based on symptoms Add these only when specific symptoms or blood work indicate a need

That said, this comparison is not as simple as tirzepatide wins, use tirzepatide. The full picture is more nuanced, and I want to give you an honest account of both what the data shows and what I actually see in our clinics

Frontiers in molecular biosciences