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Even when NPs are intended to traverse the bloodbrain barrier (BBB) for CNS delivery, neurotoxicity remains a concern: NPs can activate microglia, promote neuroinflammation, trigger excitotoxicity, and accumulate in neural tissue even without brain-targeting ligands
The main members are GLP-1 and GLP-2, both of which are produced primarily by intestinal L-cells
The landmark FLOW trial demonstrated that semaglutide reduced the risk of significant kidney events by 24% compared to placebo in patients with type 2 diabetes and chronic kidney disease
The simplest way to picture it: GLP-1 tells your gut to slow down, while amylin tells your brain you are full - through a different channel
First, you should NEVER be looking for the cheapest option
for others, it may take longer or require medical support
