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While originally developed for diabetes, both Semaglutide and Tirzepatide have separate FDA approvals for chronic weight management in adults with obesity or weight-related health issues
A.ShridharV.et al (2022)
Tuan-Mahmood T-M, McCrudden MTC, Torrisi BM, McAlister E, Garland MJ, Singh TRR, et al
The more recent SURMOUNT-5 trial directly compared tirzepatide to semaglutide and found tirzepatide superior , with 20.2% weight loss versus 13.7% for semaglutide at 72 weeks
Patient Self-Monitoring and Red Flag Symptoms Patients should be educated to recognize and report concerning symptoms promptly: Chest pain or pressure, especially with exertion Severe or persistent palpitations Unexplained shortness of breath Syncope (fainting) or near-syncope New or worsening leg swelling Persistent dizziness or lightheadedness Home blood pressure and heart rate monitoring may be beneficial for patients with hypertension or those experiencing symptoms
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