As a dual agonist, it targets both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors
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Diabetic neuropathy relief: strong evidence Alpha-lipoic acid (ALA) is one of the most well-researched supplements for diabetic peripheral neuropathy, a common complication of diabetes that can lead to nerve pain, tingling, numbness, and weakness in the limbs.19 Several clinical trials, particularly those involving intravenous ALA, have shown that doses of 600mg per day can reduce these symptoms over a matter of weeks.20 21 ALAs proposed benefit lies in its antioxidant activity
Patients should inform healthcare professionals, including surgical teams, endoscopists and dentists, about their GLP-1 medication use before procedures involving sedation or anaesthesia, due to the delayed gastric emptying effect and potential aspiration risk
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In clinical trials, patients lost an average of 1516% of their body weight over about 68 weeks when combined with diet and lifestyle changes