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What Can Disrupt Natural GLP-1 Production
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Phentermine stimulates the release of catecholamines, primarily norepinephrine (NE), and to a lesser extent, dopamine (DA) and serotonin (5-HT), in the hypothalamus and other regions of the brain
E.Herrera-CovarrubiasD.et al (2024)
If standard doses are not tolerated, clinically appropriate alternatives might include slower titration (still within SmPC guidelines), switching to a different GLP-1 receptor agonist, considering other medication classes, enhancing diet/lifestyle support, or specialist review
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