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Your provider may recommend slowing titration schedules, reducing dose frequency, or exploring alternative compounded GLP-1 formulations if chills persist or significantly impact quality of life
Although -oxidation is impaired in the setting of VPA toxicity, this metabolite has a prolonged elimination half-life and could be responsible for the prolonged coma that is sometimes observed despite the normalization in plasma VPA concentrations [17, 18]
Arne Holmgren (deceased January, 2020)
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