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If atorvastatin would bind and activate RyR2, the main isoform expressed in cardiac tissue, this could lead to dangerous arrhythmias similar to catecholaminergic polymorphic ventricular tachycardia (CPVT), frequently linked to gain-of-function mutations in RyR2 9,30
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Animals in the second group were treated with one intraperitoneal injection of polychlorinated biphenyl (Aroclor 1254) 500 mg kg -1 and were sacrificed after 7 days, while those in the third group were treated with intraperitoneal injection of 3-methylcholanthrene 20 mg -1 kg -1 day -1 for two days and were sacrificed 48 hours after treatment
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