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As clinicians, we like solid evidence-based [interventions]. Working holistically GLP-1 agonists, which are more commonly known by popular brand names, Ozempic and Wegovy, are injectable medications that mimic glucagon-like peptide-1, a natural hormone secreted in response to food intake that slows digestion and gives the brain satiety signals
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Cardiovascular outcome trials have further demonstrated that GLP-1 agonists like semaglutide reduce major adverse cardiac events in patients with established heart disease or diabetes
The BET/BRD inhibitor JQ1 attenuates diabetes-induced cognitive impairment in rats by targeting Nox4-Nrf2 redox imbalance
The most GLP-1-friendly foods of all, Wiseman says, are those that come with no labels, like produce and water
The most common adverse events are gastrointestinal in nature, including nausea (20-47% depending on dose), constipation (21%), fatigue (20%), and vomiting (8%)
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