is glp 1 venom What GLP-1 Lizard Venom: Gila Monster Discovery to Diabetes Drugs How a Venomous Desert Lizard

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10.1074/jbc.M113.512046 45 HabeggerK

The UK SmPC for Wegovy includes a warning about these findings but does not list a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) as formal contraindications, unlike in some other jurisdictions

Many people are not aware that these medications have been around since 2017 when semaglutide was first approved for use as a diabetes medication

Less Common but Serious Side Effects Some less common but more serious GLP-1 side effects are worth being aware of: Pancreatitis (inflammation of the pancreas) Gallbladder problems (including gallstones) Acute kidney injury (usually as a result of severe dehydration from vomiting or diarrhea) Diabetic retinopathy worsening (particularly in patients with rapid improvement in blood sugar control) Hypoglycemia (when combined with other diabetes medications like sulfonylureas or insulin) All GLP-1 medications also carry a warning regarding a theoretical risk of medullary thyroid carcinoma, based on animal studies

Research suggests that low glutathione levels are linked to increased nerve degeneration and inflammation (Pocernich & Butterfield, 2012, International Journal of Molecular Sciences)