Dosage frameworks for adults often reference daily magnesium provision in migraine trials that normalise serum levels within weeks, which informs formulation design for magnesium pidolate for migraine portfolios and pediatric dosing by weight [6]
Dis Markers 2006, 22(1):8393
Serine from SSP can directly bind to pyruvate kinase M2 (PKM2), the last rate-limiting enzyme of glycolysis, and promote the allosteric activation of PKM2 for the positive feedback of continuously activated glycolysis and serine synthesis (Chaneton et al., 2012)
This occurs through multiple mechanisms
Reported side effects include skin rashes, abdominal pain (in rare instances), and temporary lightning in patches, which normalizes during treatment
The potential is there, rooted in solid biological principles, but the direct proof in humans is still a frontier waiting to be explored by dedicated researchers