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These miRNAs reside in intronic regions within SREBP-1 and 2, the key transcriptional regulators of lipid metabolism 87 , and control the expression of carnitine O -octanoyltransferase (CROT), CPT1A, hydroxyacyl coenzyme A (hydroxyacyl-CoA) dehydrogenase subunit beta (HADHB), and AMPK, targeting their 3 UTR 88
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Moreover, the degree and trajectory of weight loss may have differed substantially between semaglutide users and controls, particularly if weight loss in the control group was achieved through lifestyle-related approaches rather than pharmacologic treatment, but these differences could not be measured within TriNetX
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