A phase 1, randomized, double-blind, placebo-controlled, single- and multiple-dose escalation study to evaluate the safety and pharmacokinetics/pharmacodynamics of PF-06835375, a C-X-C chemokine receptor type 5 directed antibody, in patients with systemic lupus erythematosus or rheumatoid arthritis
The most severe risk is unit confusioncalculating milligrams as micrograms results in doses 1000 lower than intended, essentially administering vehicle control while recording it as active treatment
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It is supplied in pre-filled, single-dose pens designed for self-administration, similar to insulin pens
Patients typically see reductions in blood sugar levels, blood pressure, cholesterol, and inflammation markers