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References All reference links valid and accessible on July 2026 U.S

TABLE 1 Clinical characteristics of patients with adverse events under different administration routes of Semaglutide Note: n, number of cases with available

If phase 3 results remain positive, regulatory submissions may begin in 2026, meaning orforglipron could become available in late 2026 or 2027, depending on MHRA and NICE approval timelines

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MASH (metabolic dysfunctionassociated steatohepatitis): Currently under FDA accelerated approval, pending confirmatory trial results

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