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Obviously, this adjustment is only warranted if surface area explains variability in clearance better than body weight (Chapter 14, Age, Weight, and Gender )

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Given the increasing real-world use of combined therapy and the limited HF-specific evidence base, this review summarizes current data regarding the comparative and combined effects of GLP-1 receptor agonists and SGLT2 inhibitors in HF, with emphasis on efficacy, safety, mechanistic rationale, and evidence gaps