We recommend starting with a low dose and gradually increasing it to minimize side effects such as nausea, stomach pain, or constipation
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Generally appropriate for: Adults with a BMI over 27 seeking medically-supervised weight loss People who have not achieved adequate results with diet and exercise alone Those looking for sustainable, long-term weight management support Adults without a history of thyroid or pancreatic conditions Generally not appropriate if: Pregnant or breastfeeding individuals People with a personal or family history of medullary thyroid carcinoma Those with multiple endocrine neoplasia syndrome type 2 (MEN 2) Patients with a history of pancreatitis without prior provider evaluation Common side effects: Nausea (most common, especially early in treatment, typically improves) Decreased appetite (expected and therapeutic) Mild diarrhea or constipation Occasional vomiting or stomach discomfort These typically subside as your body adjusts to the medication Individual results vary

The REWIND trial for dulaglutide showed a 12% reduction in major cardiovascular events (heart attack, stroke, or cardiovascular death) over a median of 5.4 years