Simply seeing a lower testosterone value mid-study without understanding this timeline is a misinterpretation of the data
Its importance in this discussion is that it supports the broader principle that multi-receptor agonism can outperform selective GLP-1 receptor agonism
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Thereby, a particular cluster of effects on the events ensuing after loss of vascular integrity, is evident [1,2,14,15]
Furthermore, in January 2025, the FDA approved semaglutide (Ozempic ) for reducing the risk of kidney failure and disease progression in patients with diabetes and chronic kidney disease (CKD), making it the first GLP-1 agent indicated for the treatment of CKD (Perkovic et al., 2024)
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