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In individuals with type 2 diabetes, another phase 2 clinical study demonstrated that after 12 weeks of efinopegdutide treatment, although no significant improvement in glycated hemoglobin (HbA1c) levels was observed, the effect on weight loss reached a high of 7.9%, well above the 0.7% weight reduction rate in the placebo group
Tumor miR-125a was inversely associated with IGFBP-3 mRNA and, although no survival data were presented for IGFBP-3, its low tumor expression was correlated with increased tissue Akt activation [55]