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For any approved transdermal medication, patients must always follow the specific instructions in the FDA-approved Medication Guide and prescribing information

He also points to intense side effects such as nausea, diarrhea, constipation, and vomiting as a reason for stopping

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What is also unknown is the effect on cognition, and any neuroprotective benefit, in younger or healthy individuals remains unknown, some positive results have been reported, 6 however a large scale confirmatory study is still required