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As with other GLP-1s, gastrointestinal adverse events (nausea, constipation, diarrhea and vomiting) were the most common but were typically mild-to-moderate

The question, as with combining GLP-1 and GIP receptor activity, is whether adding glucagon receptor activity to GLP-1 receptor activity exceeds the glycaemic lowering and weight loss achieved with a GLP-1 RA alone (Ambury et al, 2018

Studies in postmenopausal women have found significantly lower serum antioxidant levels alongside increased markers of oxidative damage compared to premenopausal women

Prioritize protein: Proteins are important for maintaining and building muscle