A pharmaceutical composition for intranasal administration, comprising an active ingredient and essential excipients, said active ingredient comprising 0.01% to 20% by weight (w/v) of semaglutide, or a pharmaceutically acceptable salt thereof, said pharmaceutical composition further comprising one or more permeation enhancers selected from a group consisting of cell penetrating peptides, tight junction modulating agents, and bioadhesive agents
This treatment has become increasingly popular because it provides quick and noticeable results
S.OdelbergS
The absorption factor could have some bearing but weight loss is likely to be the bigger reason, he adds

Comprehensive List of FDA-approved GLP-1 Receptor Agonists (as of mid-2025)Jun 14, 20252 min read All Available GLP-1 Receptor AgonistsBrand NameGeneric NameManufacturerOzempicSemaglutideNovo NordiskWegovySemaglutide (higher dose)Novo NordiskRybelsusSemaglutide (oral)Novo NordiskMounjaroTirzepatide (dual GLP-1/GIP)Eli LillyZepboundTirzepatide (weight loss)Eli LillyVictozaLiraglutideNovo NordiskSaxendaLiraglutide (higher dose for weight loss)Novo NordiskByettaExenatideAstraZenecaBydureon BCiseExenatide ERAstraZenecaAdlyxinLixisenatideSanofiTrulicityDulaglutideEli LillyEperzan / Tanzeum (withdrawn but notable)AlbiglutideGSK (discontinued) GLP-1 Comparison ChartNameBenefitsSide EffectsStudy LinksSemaglutide (Ozempic, Wegovy, Rybelsus)- Significant weight loss (up to 15%) - Lowers A1C ~1.5% - Cardiovascular protection (Ozempic) - Once-weekly (injection) or daily (oral)- Nausea - Vomiting - Diarrhea - Constipation - Risk of pancreatitisSTEP Trials (Wegovy) SUSTAIN Trials (Ozempic)Tirzepatide (Mounjaro, Zepbound)- Weight loss up to 20% - Superior A1C reduction (~2%+) - Combines GLP-1 + GIP effects - Weekly injection- GI upset - Fatigue - Constipation - Gallbladder issues (rare)SURMOUNT Trials (Zepbound) SURPASS Trials (Mounjaro)Liraglutide (Victoza, Saxenda)- A1C reduction ~1-1.5% - Weight loss up to 8% - Cardiovascular benefit (Victoza) - Daily injection- Nausea - Headache - Injection site irritation - Possible pancreatitisLEADER Trial (Victoza) SCALE Trial (Saxenda)Exenatide (Byetta, Bydureon)- A1C reduction ~1% - Weight neutral or mild loss - Twice-daily or weekly injection- Nausea - Hypoglycemia (esp

Through fat and lean and thick and thin and, to quote Mel Brooks, through thin, the Tribune has been good to me